Research Associate
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Employer: Imperial College London |
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Job location: London UK |
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Apply before: 24 Oct 2019 |
Summary
We are seeking an outstanding chemical biologist to work on an ongoing drug discovery and validation project in the field of cancer immunotherapy, in the groups of Professor Ed Tate (Department of Chemistry) and Dr Doryen Bubeck (Department of Life Sciences). The role will involve a high degree of teamwork and multidisciplinary research.
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Duties and responsibilities
CD59 is a small extracellular protein that has been shown to significantly restrict the effectiveness of anticancer monoclonal antibody therapies, including trastuzumab (HER2-positive breast cancer) and rituximab (B-cell non-Hodgkin’s Lymphoma).
Your research will focus on structure-guided optimisation to enhance the potency and physicochemical properties of CD59-binders for subsequent in vivo studies. You will use state-of-the-art Q-TOF LC/MS analysis technology within the Agilent Measurement Suite at the Molecular Sciences Research Hub at Imperial’s new White City Campus.
You will collaborate extensively with scientists in the Tate group at the state-of-the art £150M Molecular Sciences Research Hub at Imperial’s new White City Campus, and with scientists from the Bubeck group at our South Kensington Campus
Essential requirements
You will need a PhD (or be in the final stages of completion) in a molecular science (for example, chemical biology, molecular biology, biochemistry, medicinal chemistry, etc.), or an equivalent level of professional qualifications and experience.
You will also need experience in medicinal chemistry and experience using X-ray crystallography/structure-guided design.
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